What’s even better are the AWESOME MOSS BIOREAKTORS they used to do it!

Is that Luke Skywalker in there? The only thing that could possibly make this image more awesome would be some lightning shooting out of the tops of those reaktors (cannot help self -- the Germanic K is too much fun). Eat your hearts out, nuclear physicists! Click image for source.

Now I ask you, does it get any cooler than bionic moss? Although this does beg the question: Why, on God’s Green Earth?

Because this bizarre, dissociated, barely recognizable moss could provide a cheaper, easier and more economical way to produce drugs like insulin. Right now such proteins are produced in relatively costly and difficult-to-maintain mammalian cell cultures with organic vegan-class nutritional and environmental requirements. Only industrial countries can handle the complexities, and demand is outstripping supply.

Moss, on the other hand, makes its own food. All it needs is some light, a few inexpensive salts, water, and room to grow. Have Chlorophyll — Will Transcribe. A simple growth solution also makes purification of the product protein much easier, according to the paper. With such a set-up, even developing nations may one day be able to make insulin for their own diabetics. Yes, better living through biokemistry. : )

For instance, a press release on one of the coolest things I’ve seen in a long time includes this sentence, seemingly lifted from Timmy’s 3rd grade report on mosses:

At first glance, mosses and human beings have little in common.

Gee, ya think? I’m imagining myself at a coffee shop holding a cup of steaming tea and sitting across the table from a noticeably uncomfortable bryophyte.

Cough. *Blink*

Me: So, read anything interesting lately?

Moss: No.

See? Not much in common. Strangely, this doesn’t differ greatly from most of my actual dates.

I don’t want to seem too hard on the author here, since 1. the release was probably first written in German, and 2. this is actually one of the clearer and more helpful press releases I’ve read. In any case . . .

Scientists from ETH Zurich and the University of Freiburg im Breisgau report that they were able to insert DNA from humans and bacteria into the moss Physcomitrella patens (sounds suspiciously close to “patent”) and the moss was able to manufacture human proteins without any further help. Yes, they basically cut and paste. And the moss said: OK! Cool!

The protonema of Physcomitrella patens. When the spore of this moss lands on a suitable spot, it starts growing into filaments like these. Given enough time, these little filaments will grow into a full-grown moss plant. You can see the chloroplasts, or light harvesting equipment, as little green circles.

For those of you unfamiliar with the Way of the Cell, DNA makes RNA (with the help of proteins called RNA polymerases), and RNA makes proteins (with the help of cell organelles called ribosomes). The reason this moss-cular feat is astounding is that doing the same thing with flowering plants will get you nada. The mammalian gene start and end sequences have evolved themselves right out of business when placed in a similarly much-modified flowering plant. Not that there’s much of a reason that that would *ever* happen in nature. Now in an evil mad plant scientist laboratory, on the other hand . . . Belgians + petunias = Brussels sprouts. Mwa ha ha ha ha ha . . . . .

How is it mosses can do what so-called “higher” plants cannot? It’s a mistake to think of mosses as “primitive” in the sense of “inferior”. Both mosses and flowering plants have ancestors that were alive at the same time. What mosses are is “less-derived”, in biologist-speak. The lineage that gave us mosses just didn’t change as much over time as the lineage that produced flowering plants, because they found they were well-adapted as-is to their particular niche (forests, rocks, sidewalk cracks, and the sets of “Lord of the Rings” adaptations). Like sharks, they found a sweet gig and they stuck with it.

According to Ralf Reski, botanist and co-author of the paper announcing this discovery, as part of this cozying into a niche relatively early on for multicellular life (moss seem to have sprouted out of the ocean and then pretty much called it a day) mosses have stayed genetic generalists. And this easy-going gene-set enables them to translate a wide range of DNA. In fact, hold on to your hats . . .

This cross-kingdom conservation of mammalian and moss protein production machineries is phylogenetically profound, and has several implications for basic and applied research. Comparative genomics, as well as functional studies, have recently established major differences in metabolic pathways and gene function between flowering plants and P. patens, and have suggested that a substantial moss gene pool is more closely related to mammals than to flowering plants (Frank et al., 2007; Rensing et al., 2008).

—Plant Biotechnology Journal, Volume 7, Issue 1, 2009. Pages: 73–86

Dude! An article in the Plant Biotechnology Journal just blew my mind!

Who knew? Well, maybe John Wyndham.

In my next post, we’ll take a look at what on Earth possessed these scientists to stuff human genes into a soft, green, cushiony object and at why biology is WAY cooler than nuclear physics. Stay tuned.